Enclomiphene Citrate

Enclomiphene citrate capsules may assist those with male hypogonadism, a condition characterized by low testosterone levels. Hypogonadism may cause fatigue, decreased libido, and erectile dysfunction.^[1] Enclomiphene citrate, a selective estrogen receptor modulator (SERM), may help increase levels of precursor hormones LH and FSH which may help stimulate the body’s natural production of testosterone.^[2] Enclomiphene citrate may assist with the preservation of the feedback mechanisms of the hypothalamic-pituitary-gonadal (HPG) axis, which may help lower the risk of testicular atrophy and infertility commonly associated with testosterone replacement therapy.^[3][4]

Store this medication at 68°F to 77°F (20°C – 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

1. Kumar P, Kumar N, Thakur DS, Patidar A. Male hypogonadism: Symptoms and treatment. J Adv Pharm Technol Res. 2010 Jul;1(3):297-301. doi: 10.4103/0110-5558.72420. PMID: 22247861; PMCID: PMC3255409. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255409/- LinkOpens in New Tab
2. Wiehle RD, Fontenot GK, Wike J, Hsu K, Nydell J, Lipshultz L; ZA-203 Clinical Study Group. Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. Fertil Steril. 2014 Sep;102(3):720-7. doi: 10.1016/j.fertnstert.2014.06.004. Epub 2014 Jul 17. PMID: 25044085.
3. Kaminetsky J, Werner M, Fontenot G, Wiehle RD. Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel. J Sex Med. 2013 Jun;10(6):1628-35. doi: 10.1111/jsm.12116. Epub 2013 Mar 26. PMID: 23530575.
4. Rodriguez KM, Pastuszak AW, Lipshultz LI. Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert Opin Pharmacother. 2016 Aug;17(11):1561-7. doi: 10.1080/14656566.2016.1204294. Epub 2016 Jul 4. PMID: 27337642; PMCID: PMC5009465.